International Immunology, Vol 10, 1891-1895, Copyright © 1998 by Oxford University Press
S Shiozawa, S Hayashi, Y Tsukamoto, H Goko, H Kawasaki, T Wada, K Shimizu, N Yasuda, N Kamatani, K Takasugi, Y Tanaka, K Shiozawa and S Imura
We have searched the human genome for genes that predispose to rheumatoid
arthritis (RA) using fluorescence-based microsatellite marker analysis and
affected sib-pair linkage study. A panel of 41 Japanese families, each with
at least two affected siblings, was typed for genome-wide 358 polymorphic
microsatellite marker loci. Markers were amplified by the PCR using
fluorescence-tagged primers and sized based on the difference of CA repeats
on DNA. Linkage analysis was made using maximum lod score (MLS). The MLS
for D1S214 and D8S556 was 3.27 and 3.33, while the MLS for the HLA-DRB1
region was <3.0. According to detailed analysis by single-point analysis
using MAPMAKER/SIBS, the MLS for D1S253 and D1S214 was 3.77 and 3.58. The
MLS by multipoint analysis was 6.13 for D1S253. The MLS for D8S556 by
single-point analysis was 4.20. The MLS for DXS1232 was 2.35 by
single-point analysis, whereas the MLS for the region 2 cM right to DXS1232
and the region between DXS1227 and DXS1200 was 3.03 and 2.93 by multi-point
analysis. Three principal chromosome regions of linkage, D1S253/214, D8S556
and DXS1232, have been identified which we call RA1, RA2 and RA3 for RA
disease loci.
ARTICLES
Identification of the gene loci that predispose to rheumatoid arthritis
Kobe University School of Medicine Faculty of Health Science, Sumaku, Japan.
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