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International Immunology, Vol 10, 1819-1823, Copyright © 1998 by Oxford University Press

ARTICLES

Differential display analysis of murine encephalitogenic mRNA [In Process Citation]

MC Jeong, L Izikson, A Uccelli, S Brocke and JR Oksenberg
Department of Neurology, School of Medicine, University of California, San Francisco 94143, USA.

Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease which can be induced by inoculation with activated CD4+ T lymphocytes specific for myelin proteins. It has been postulated that autoreactive Th1-type CD4+ cells are responsible for the lesions, whereas autoreactive Th2-type cells suppress or modulate the disease. However, the mechanisms involved in the development of inflammatory lesions and neurologic deficits in EAE have not been fully described, and probably involve a complex array of mediators and alternative or redundant pathways. To identify additional factors associated with the pathological role of T cells in EAE, we adapted the differential mRNA display technique to fingerprint the transcripts expressed by encephalitogenic and non-encephalitogenic T cells. Using 60 primer combinations, 21 differentially expressed cDNAs were identified. Among them 13 are known sequences, including IL-3 in non- encephalitogenic lymphocytes. Their relevance for the disease process is discussed.
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