International Immunology, Vol 10, 1703-1711, Copyright © 1998 by Oxford University Press
RA Manz, M Lohning, G Cassese, A Thiel and A Radbruch
Recent studies have shown that persistent specific antibody titer is
provided by long-lived plasma cells (PC) which constitute a new kind of
'memory-providing cells'. In the present study, we examine the role of
antigen for the long-term survival of PC and the maintenance of specific
serum antibody titers. Using a novel cytometric technology, to identify and
isolate antigen-specific PC, we analyzed long-lived PC of BALB/c mice,
during their development (between day 1 and 10) after secondary
immunization with ovalbumin (OVA) and in the phase of the established
immune reaction. Most if not all OVA-specific PC were generated within a
few days after immunization. Within approximately 3 weeks, they matured, as
indicated by down-regulation of expression of MHC class II. These PC are
long lived and located in spleen and bone marrow. Upon adoptive transfer,
OVA-specific PC from bone marrow, but not memory B cells, conferred
specific and long-lasting antibody titers to antigen-free IgH syngeneic
recipients. In response to antigenic challenge, new OVA-specific
antibody-secreting cells were generated from transferred memory B cells.
Antibody secretion by long-lived PC was not affected. Our results confirm
that persistent antibody titers are provided by long-lived PC, independent
of memory B cells and demonstrate that this humoral memory is inert to
antigen.
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Survival of long-lived plasma cells is independent of antigen [In Process Citation]
Deutsches Rheuma-Forschungszentrum, Berlin, Germany.
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