International Immunology, Vol 10, 1693-1702, Copyright © 1998 by Oxford University Press
C Madry, Y Laabi, I Callebaut, J Roussel, A Hatzoglou, M Le Coniat, JP Mornon, R Berger and A Tsapis
The BCMA gene is a new gene discovered by the molecular analysis of a
t(4;16) translocation, characteristic of a human T cell lymphoma. It has no
significant similarity with any known protein or motif, so that its
function was unknown. This report describes the cloning of murine BCMA cDNA
and its genomic counterpart. The mouse gene is organized into three exons,
like the human gene, and lies in murine chromosome 16, in the 16B3 band,
the counterpart of the human chromosome 16p13 band, where the human gene
lies. Murine BCMA cDNA encodes a 185 amino acids protein (184 residues for
the human), has a potential central transmembrane segment like the human
protein and is 62% identical to it. The murine BCMA mRNA is found mainly in
lymphoid tissues, as is human BCMA mRNA. Alignment of the murine and human
BCMA protein sequences revealed a conserved motif of six cysteines in the
N-terminal part, which strongly suggests that the BCMA protein belongs to
the tumor necrosis factor receptor (TNFR) superfamily. Human BCMA is the
first member of the TNFR family to be implicated in a chromosomal
translocation.
ARTICLES
The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily
INSERM CJF 95-02, Faculte de Medecine Paris-Sud, Universite Paris XI, Clamart, France.
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