International Immunology

International Immunology publishes a broad range of experimental and theoretical studies in molecular and cellular immunology conducted in laboratories throughout the world.

Article collections

As a prelude to the 14th International Congress of Immunology to be held in Kobe, Japan, in 2010, prominent researchers in Japan review the history of research activities in various research fields in Japan and also update recent progress in those topics worldwide.

This series of articles on Immunology in Japan will appear in the journal throughout 2009 and 2010.

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Featured article - December issue

Regulatory and pro-inflammatory phenotypes of myelin basic protein-autoreactive T cells in multiple sclerosis

Autoreactive T cells specific for myelin antigens, such as MBP are considered to play an important role in the pathogenesis of multiple sclerosis (MS). This study showed that MBP83–99-specific T cells generated from MS patients (n = 7) contain pro-inflammatory and regulatory subsets of distinct phenotypes. The pro-inflammatory subset produced high amounts of IFN-y, IL-6, IL-21 and IL-17...