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International Immunology publishes a broad range of experimental and theoretical studies in molecular and cellular immunology conducted in laboratories
throughout the world.
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Review articlesEditor's choice: featured articles (free access)
Featured article – February issue
Sulfatide blocks αGC binding to CD1d in DCs
Non-invariant NKT (non-iNKT) cells bind sulfatide and counteract iNKT cells. Inaba and colleagues (p. 129) report that, even in the absence of non-iNKT cells, sulfatide reduces formation of α-galactosyl ceramide (αGC)–CD1d complexes
on dendritic cells (DCs) and thereby inhibits αGC-mediated iNKT cell activation. The authors conclude that sulfatide competes
with αGC for loading onto CD1d in the endocytic pathway of DCs. Read more
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Editor-in-Chief of International Immunology is awarded 2011 Japan Prize for Bioscience and Medical Sciences
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