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International Immunology publishes a broad range of experimental and theoretical studies in molecular and cellular immunology conducted in laboratories throughout the world.

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Featured article – June issue

RP105 is important for MZ B cell Function

RP105 (radioprotective 105) is a TLR4 homologue expressed on marginal-zone (MZ) B cells, and Nagai et al. (p. 389) define its roles. Simultaneous crosslinking of RP105 and TLR4 enhances survival, differentiation to plasma cells and IgM production. RP105-deficient MZ B cells do not produce such IgM. The authors conclude that RP105 interacts extensively with TLR4 in splenic B cells.
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